Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents
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چکیده
منابع مشابه
Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents
Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of these drugs in breast cancer and other tumor types, clinical response remains variable. Tumor-associated macrophages (TAMs) suppress the duration of Taxol-induced mitotic arrest in breast cancer cells and promote earlier mitotic slippage...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2017
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2017.03.038